MICRONUCLEUS TEST OF MOFEZOLAC (N-22)

Micronucleus Test of Mofezolac

---・-A micronucleus test using BDFi male mice was conducted in order to evaluate the in vive mutagenicity of mofezolac (N-22). N-22 was orally administered at doses of 75, 150, 300 arid 600 mglkg, with a sampling time of 24 hr. The frequency of polychromatic erythrocytes with micronuclei was O,07-O,08% in the groups treated with N-22 and did not differ markedly from that of the vehicle control ...

REPORT ON MICRONUCLEUS TEST ( MNT ) in vitro

Micronucleus test on gas station attendants.

In the present study, the micronucleus test was applied in exfoliated cells of buccal mucosa to assess the mutagenicity risk associated with occupational exposure for gas station attendants. For each individual, 2000 exfoliated buccal cells were analyzed for micronucleus frequency. A highly significant difference was found between exposed and control groups. Likewise, a significant difference w...

Cytotoxicity of Mouthrinses on Epithelial Cells by Micronucleus Test

OBJECTIVES To determine the cytotoxicity of three commercial mouthrinses Klorhex, Andorex and Tanflex on buccal epithelial cells using micronucleus (MN) test. MATERIALS AND METHODS 28 patients with aged 16-24 undergone three mouthrinses' application were analyzed before and after one week exposure. Physiologic saline was used for the control group. The MN incidence was scored in the buccal ep...

ECVAM retrospective validation of in vitro micronucleus test (MNT)

In the past decade several studies comparing the in vitro chromosome aberration test (CAT) and the in vitro micronucleus test (MNT) were performed. A high correlation was observed in each of the studies (>85%); however, no formal validation for the micronucleus in vitro assay had been carried out. Therefore, a working group was established by the European Centre for the Validation of Alternativ...